The main Macmillan way runs from Boston on the Lincolnshire coast to the Dorset coast at Abbotsbury. It is called the Macmillan Way because all the funds that are raised are donated to Macmillan Cancer Support.

The Macmillan Way is 290 miles in length and uses existing footpaths, bridleways and byways with small stretches of minor roads when unavoidable. It runs across beautiful open fen country for the first 30 miles then follows the oolitic limestone belt and passes through small towns and villages.